Stretch mark Care

The present invention relates to a cosmetic method for preventing and/or treating skin stretchmarks, and to the use of a composition to prepare a dermatological medicinal product for preventing and/or treating stretchmarks.

Stretchmarks are visible marks on the skin resulting from the skin being stretched due to a gain in weight or mechanical stresses, which usually concern women, after puberty or a first pregnancy. About 50% of pregnant women develop stretchmarks, on the thighs, the abdomen and/or the breasts. Stretchmarks may also appear during physiological or pathological states such as obesity, tuberculosis and typhoid fever, and also during a relatively intensive dietary regime. The treatment of stretchmarks has been described, for example, in the article by P. Zheng et al., “Anatomy of striae”, British Journal of Dermatology 112:185-193 (1985), in which it is especially reported that stretchmarks are scars resulting from an inflammation process which destroys elastic fibers.

Since then, many compounds have been proposed as active principles for treating stretchmarks, such as, for example, tretinoin (or all-trans-retinoic acid). According to the article by R. E. B. Watson et al., “Fibrillin microfibrils are reduced in skin exhibiting striae distensae”, British Journal of Dermatology 138:931-937 (1998), it would appear that tretinoin has an anti-stretchmark action with a tendency toward essentially restoring the network of fibrillins, which are the main constituent of the microfibrils within elastic fibers, when compared with other constituents of the extracellular matrix.

However, although the active compounds of the prior art produce a stretchmark-regressing effect, it nevertheless remains that the results obtained are not entirely satisfactory, in particular given the well-known skin intolerance problem of tretinoin. There has thus hitherto been a real demand for the development of a product for efficiently preventing and/or treating, with acceptable skin tolerance, this complex and particularly unattractive problem of stretchmarks.

It has now been found, entirely surprisingly and unexpectedly, that the use of certain peptides makes it possible entirely significantly to prevent and/or treat skin stretchmarks, in a manner which is acceptable as regards skin tolerance.

SUMMARY

A subject of the present invention is thus a cosmetic method for preventing and/or treating skin stretchmarks, characterized in that a composition is applied to the areas of skin liable to form or comprising stretchmarks, this composition comprising, in a suitable vehicle, at least one anti-stretchmark agent chosen from the group consisting of soya peptides and tripeptides consisting of the amino acids glycine, histidine and lysine, and mixtures of these peptides.

According to the present invention, the expression “prevention of skin stretchmarks” means an action which prevents or at least reduces the formation of stretchmarks, i.e. their length, width and/or depth, in the context of a cosmetic or dermatological treatment, by applying the composition before and during an event known to cause the appearance of stretchmarks, such as pregnancy. According to the present invention, the expression “treatment of skin stretchmarks” means an action which visibly and measurably regresses, i.e. resorbs, in the context of a cosmetic or dermatological treatment, already-formed stretchmarks, i.e. their length, width and/or depth.

Thus, the composition used according to the invention may be applied to areas of skin liable to form stretchmarks, comprising stretchmarks in the process of being formed or even comprising already-formed stretchmarks.

The soya peptides in the composition used according to the present invention may be any peptide obtained by hydrolysis of proteins extracted from soya, under operating conditions known to those skilled in the art, in other words any soya protein hydrolysate. These soya peptides are preferably peptides which have also undergone a fermentation with a strain of microorganism. In general, a fermented soya peptide is obtained by placing a soya peptide in a fermenter in the presence of glucose, mineral salts and a given strain of microorganism, under controlled temperature, pH, oxygenation and time conditions. After the fermentation, the fermented soya peptide is obtained by conventional separating and filtering operations. This technique is especially used by the company Coletica which thus sells various fermented plant protein hydrolysates. The fermented or unfermented soya peptides in the composition used according to the present invention preferably have a molecular weight of between about 200 and about 20,000 daltons, as measured, for example, by electrophoresis.

One soya peptide which is particularly preferred for the composition used according to the invention is the fermented peptide known as “Phytokine®” as sold by the company Coletica.

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