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กลุ่มดูแลรักษาสิว ; ACNE TREATMENT
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Antioxidants

 

   Supplement

Antioxidants

   Description

The term "antioxidant" refers to the activity possessed by numerous vitamins, minerals and other phytochemicals to serve as protection against the damaging effects of highly reactive molecules known as free radicals. Free radicals have the ability to chemically react with, and damage, many structures in the body. Particularly susceptible to oxidative damage are the cell membranes of virtually all cells and the very source of our genetic material DNA. Free radical reactions and oxidative damage have been linked to many of the diseases of aging such as heart disease and cancer.

   Claims

  • Cellular protection
  • Anti-aging
  • Cancer prevention
  • Heart disease prevention
  • Anti-wrinkle (topical and oral)
  • Promotes vision and eyesight
  • Enhanced immune function

   Theory

The free radical theory of aging (and disease promotion) holds that through a gradual accumulation of microscopic damage to our cell membranes, DNA, tissue structures and enzyme systems, we begin to lose function and are predisposed to disease. In the case of athletes or other avid exercisers, oxidative damage may be elevated due to increased production of free radicals during intense activity. Although the body increases its production of endogenous antioxidant enzymes (glutathione peroxidase, catalase, superoxide dismutase), it may be theorized that supplemental levels of exogenous or dietary antioxidants may be warranted to prevent excessive oxidative damage to muscles, mitochondria and other tissues. In theory, a suppression of damage during exercise may translate into an enhanced ability to recover from exhaustive exercise and a subsequent increase in athletic performance.

   Scientific Support

Thousands of studie have clearly documented the beneficial effects of dozens of antioxidant nutrients
There is certainly no shortage of nutrients and phytochemicals that possess significant antioxidant activity in the test tube. Increased dietary intake of antioxidant nutrients, such as vitamins C and E, minerals such as selenium and various phytonutrients such as extracts from grape seed, pine bark and green tea have all been linked to reduced rates of oxidative damage as well as reduced incidence of chronic diseases such as heart disease and cancer.

   Safety

At the typically recommended levels, the majority of antioxidants appear to be quite safe. For example, vitamin E, one of the most powerful membrane bound antioxidants also has one of the best safety profiles. Doses of 100-400 IU have been linked to significant cardiovascular benefits with no side effects. Vitamin C , another powerful antioxidant, can help to protect and restore the antioxidant activity of vitamin E, and is considered safe up to doses of 500-1,000 mg. Higher doses of vitamin C are not recommended because of concerns that such levels may cause an "unbalancing" of the oxidative systems and actually promote oxidative damage instead of preventing it. Another popular antioxidant, beta-carotene, is somewhat controversial as a dietary supplement. Although diets high in fruits and vegetables might deliver approximately 5-6 mg of carotenes daily, these would be a mixture of beta-carotene and other naturally occurring carotenoids. Concern was raised several years ago by studies in which high dose beta-carotene supplements appeared to promote lung cancer in heavy smokers. Those studies provided beta-carotene supplements of 20-60 mg about 5-10 times the levels that could reasonably be expected in the diet.

   Value

The 4 key nutritional antioxidants, vitamins C and E, beta-carotene and selenium, are widely available as dietary supplements, well studied and relatively inexpensive. As mentioned above, there are a multitude of fruit and vegetable phytonutrient extracts available that also possess significant antioxidant activity. In most cases, phytonutrient extracts tend to be quite expensive, although their potent antioxidant activity may allow dosages to be extremely small. Some of the more popular antioxidant nutrients found in commercial dietary supplements also include Zinc, Copper, Ginkgo biloba, Grape seed extract , Pine bark extract, Lycopene , Lutein , Quercetin , and Alpha lipoic acid as well as dozens of others.

   Dosage

1. Vitamin E 100 to 400 IU per day
2. Vitamin C 250 to 500 mg per day
3. Beta-carotene 5 to 6 mg per day
4. Selenium 70 to 200 mcg per day

   References

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Eur J Appl Physiol Occup Physiol. 1998;77(1-2):157-63. 8. Child RB, Wilkinson DM, Fallowfield JL, Donnelly AE. Elevated serum antioxidant capacity and plasma malondialdehyde concentration in response to a simulated half-marathon run. Med Sci Sports Exerc. 1998 Nov;30(11):1603-7. 9. Child RB, Wilkinson DM, Fallowfield JL. Resting serum antioxidant status is positively correlated with peak oxygen uptake in endurance trained runners. J Sports Med Phys Fitness. 1999 Dec;39(4):282-4. 10. Clarkson PM, Thompson HS. Antioxidants: what role do they play in physical activity and health? Am J Clin Nutr. 2000 Aug;72(2 Suppl):637S-46S. 11. Clarkson PM. Micronutrients and exercise: anti-oxidants and minerals. J Sports Sci. 1995 Summer;13 Spec No:S11-24. 12. Davison A, Rousseau E, Dunn B. Putative anticarcinogenic actions of carotenoids: nutritional implications. Can J Physiol Pharmacol. 1993 Sep;71(9):732-45. 13. Dragan I, Dinu V, Mohora M, Cristea E, Ploesteanu E, Stroescu V. Studies regarding the antioxidant effects of selenium on top swimmers. Rev Roum Physiol. 1990 Jan-Mar;27(1):15-20. 14. Dufaux B, Heine O, Kothe A, Prinz U, Rost R. Blood glutathione status following distance running. Int J Sports Med. 1997 Feb;18(2):89-93. 15. Duthie GG, Robertson JD, Maughan RJ, Morrice PC. Blood antioxidant status and erythrocyte lipid peroxidation following distance running. Arch Biochem Biophys. 1990 Oct;282(1):78-83. 16. Evans JR, Henshaw K. Antioxidant vitamin and mineral supplementation for preventing age-related macular degeneration. Cochrane Database Syst Rev. 2000;(2):CD000253. 17. Gerster H. The role of vitamin C in athletic performance. J Am Coll Nutr. 1989 Dec;8(6):636-43. 18. Ginsburg GS, Agil A, O'Toole M, Rimm E, Douglas PS, Rifai N. Effects of a single bout of ultraendurance exercise on lipid levels and susceptibility of lipids to peroxidation in triathletes. JAMA. 1996 Jul 17;276(3):221-5. 19. Grievink L, Jansen SM, van't Veer P, Brunekreef B. Acute effects of ozone on pulmonary function of cyclists receiving antioxidant supplements. Occup Environ Med. 1998 Jan;55(1):13-7. 20. Grievink L, Smit HA, Veer P, Brunekreef B, Kromhout D. Plasma concentrations of the antioxidants beta-carotene and alpha-tocopherol in relation to lung function. Eur J Clin Nutr. 1999 Oct;53(10):813-7. 21. Grievink L, Zijlstra AG, Ke X, Brunekreef B. Double-blind intervention trial on modulation of ozone effects on pulmonary function by antioxidant supplements. Am J Epidemiol. 1999 Feb 15;149(4):306-14. 22. Hellsten Y, Apple FS, Sjodin B. Effect of sprint cycle training on activities of antioxidant enzymes in human skeletal muscle. J Appl Physiol. 1996 Oct;81(4):1484-7. 23. Jenkins DJ. Optimal diet for reducing the risk of arteriosclerosis. Can J Cardiol. 1995 Oct;11 Suppl G:118G-122G. 24. Ji LL. Oxidative stress during exercise: implication of antioxidant nutrients. Free Radic Biol Med. 1995 Jun;18(6):1079-86. 25. Jonat W. Nonhormonal prevention of breast cancer. Med Klin. 2000 Jun;95 Suppl 1:9-13. 26. Kaikkonen J, Kosonen L, Nyyssonen K, Porkkala-Sarataho E, Salonen R, Korpela H, Salonen JT. Effect of combined coenzyme Q10 and d-alpha-tocopheryl acetate supplementation on exercise-induced lipid peroxidation and muscular damage: a placebo-controlled double-blind study in marathon runners. Free Radic Res. 1998 Jul;29(1):85-92. 27. Kanter M. Free radicals, exercise and antioxidant supplementation. Proc Nutr Soc. 1998 Feb;57(1):9-13. 28. Kostka T, Drai J, Berthouze SE, Lacour JR, Bonnefoy M. Physical activity, fitness and integrated antioxidant system in healthy active elderly women. Int J Sports Med. 1998 Oct;19(7):462-7. 29. Liu ML, Bergholm R, Makimattila S, Lahdenpera S, Valkonen M, Hilden H, Yki-Jarvinen H, Taskinen MR. A marathon run increases the susceptibility of LDL to oxidation in vitro and modifies plasma antioxidants. Am J Physiol. 1999 Jun;276(6 Pt 1):E1083-91. 30. Marzatico F, Pansarasa O, Bertorelli L, Somenzini L, Della Valle G. Blood free radical antioxidant enzymes and lipid peroxides following long-distance and lactacidemic performances in highly trained aerobic and sprint athletes. J Sports Med Phys Fitness. 1997 Dec;37(4):235-9. 31. McKeown-Eyssen G, Holloway C, Jazmaji V, Bright-See E, Dion P, Bruce WR. A randomized trial of vitamins C and E in the prevention of recurrence of colorectal polyps. Cancer Res. 1988 Aug 15;48(16):4701-5. 32. Nielsen AN, Mizuno M, Ratkevicius A, Mohr T, Rohde M, Mortensen SA, Quistorff B. No effect of antioxidant supplementation in triathletes on maximal oxygen uptake, 31P-NMRS detected muscle energy metabolism and muscle fatigue. Int J Sports Med. 1999 Apr;20(3):154-8. 33. Okamura K, Doi T, Hamada K, Sakurai M, Yoshioka Y, Mitsuzono R, Migita T, Sumida S, Sugawa-Katayama Y. Effect of repeated exercise on urinary 8-hydroxy-deoxyguanosine excretion in humans. Free Radic Res. 1997 Jun;26(6):507-14. 34. Oostenbrug GS, Mensink RP, Hardeman MR, De Vries T, Brouns F, Hornstra G. Exercise performance, red blood cell deformability, and lipid peroxidation: effects of fish oil and vitamin E. J Appl Physiol. 1997 Sep;83(3):746-52. 35. Ortenblad N, Madsen K, Djurhuus MS. Antioxidant status and lipid peroxidation after short-term maximal exercise in trained and untrained humans. Am J Physiol. 1997 Apr;272(4 Pt 2):R1258-63. 36. Peters EM, Goetzsche JM, Grobbelaar B, Noakes TD. Vitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runners. Am J Clin Nutr. 1993 Feb;57(2):170-4. 37. Pierson WE, Covert DS, Koenig JQ, Namekata T, Kim YS. Implications of air pollution effects on athletic performance. Med Sci Sports Exerc. 1986 Jun;18(3):322-7. 38. Pincemail J, Lecomte J, Castiau J, Collard E, Vasankari T, Cheramy-Bien J, Limet R, Defraigne J. Evaluation of autoantibodies against oxidized LDL and antioxidant status in top soccer and basketball players after 4 months of competition. Free Radic Biol Med. 2000 Feb 15;28(4):559-65. 39. Powers SK, Hamilton K. Antioxidants and exercise. Clin Sports Med. 1999 Jul;18(3):525-36. 40. Rautalahti M, Huttunen J. Antioxidants and carcinogenesis. Ann Med. 1994 Dec;26(6):435-41. 41. Rokitzki L, Hinkel S, Klemp C, Cufi D, Keul J. Dietary, serum and urine ascorbic acid status in male athletes. Int J Sports Med. 1994 Oct;15(7):435-40. 42. Rokitzki L, Logemann E, Huber G, Keck E, Keul J. alpha-Tocopherol supplementation in racing cyclists during extreme endurance training. Int J Sport Nutr. 1994 Sep;4(3):253-64. 43. Sanchez-Quesada JL, Jorba O, Payes A, Otal C, Serra-Grima R, Gonzalez-Sastre F, Ordonez-Llanos J. Ascorbic acid inhibits the increase in low-density lipoprotein (LDL) susceptibility to oxidation and the proportion of electronegative LDL induced by intense aerobic exercise. Coron Artery Dis. 1998;9(5):249-55. 44. Schroder H, Navarro E, Tramullas A, Mora J, Galiano D. Nutrition antioxidant status and oxidative stress in professional basketball players: effects of a three compound antioxidative supplement. Int J Sports Med. 2000 Feb;21(2):146-50. 45. Taylor PR, Li B, Dawsey SM, Li JY, Yang CS, Guo W, Blot WJ. Prevention of esophageal cancer: the nutrition intervention trials in Linxian, China. Linxian Nutrition Intervention Trials Study Group. Cancer Res. 1994 Apr 1;54(7 Suppl):2029s-2031s. 46. Tiidus PM, Houston ME. Vitamin E status and response to exercise training. Sports Med. 1995 Jul;20(1):12-23. 47. Tiidus PM, Pushkarenko J, Houston ME. Lack of antioxidant adaptation to short-term aerobic training in human muscle. Am J Physiol. 1996 Oct;271(4 Pt 2):R832-6. 48. Tiidus PM. Radical species in inflammation and overtraining. Can J Physiol Pharmacol. 1998 May;76(5):533-8. 49. Vasankari T, Kujala U, Sarna S, Ahotupa M. Effects of ascorbic acid and carbohydrate ingestion on exercise induced oxidative stress. J Sports Med Phys Fitness. 1998 Dec;38(4):281-5. 50. Vasankari TJ, Kujala UM, Rusko H, Sarna S, Ahotupa M. The effect of endurance exercise at moderate altitude on serum lipid peroxidation and antioxidative functions in humans. Eur J Appl Physiol Occup Physiol. 1997;75(5):396-9. 51. Vasankari TJ, Kujala UM, Vasankari TM, Vuorimaa T, Ahotupa M. Increased serum and low-density-lipoprotein antioxidant potential after antioxidant supplementation in endurance athletes. Am J Clin Nutr. 1997 Apr;65(4):1052-6. 52. Ward JA. Should antioxidant vitamins be routinely recommended for older people? Drugs Aging. 1998 Mar;12(3):169-75. 53. Williams MH. Vitamin supplementation and athletic performance. Int J Vitam Nutr Res Suppl. 1989;30:163-91. 54. Woteki CE. Applications of antioxidants in physiologically functional foods. Consumption, intake patterns, and exposure. Crit Rev Food Sci Nutr. 1995 Jan;35(1-2):143-7. 55. Yu BP, Kang CM, Han JS, Kim DS. Can antioxidant supplementation slow the aging process? Biofactors. 1998;7(1-2):93-101.

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